Affiliation:
1. School of Pharmacy, Gujarat, India
Abstract
Animal models play a critical role in diabetes research, aiding in the comprehension of both type 1 and type 2 diabetes pathogenesis and the assessment of potential therapeutic interventions. These models offer numerous advantages, including the ability to induce stable hyperglycemia and hyperlipidemia, minimal variability, and the opportunity to study genetic mutations and single gene effects. However, they also present limitations such as lengthy induction periods, fluctuating glucose parameters, potential toxicity to other organs, and high costs. Various screening models, encompassing in vitro assays and models like Alloxan-induced and Streptozotocin-induced diabetes, serve as valuable tools for investigating diabetes and testing drug efficacy. The selection of an appropriate model requires careful consideration of specific research objectives. Despite their limitations, animal models continue to be indispensable for advancing our understanding of diabetes and developing effective treatments.
Publisher
IP Innovative Publication Pvt Ltd
Reference18 articles.
1. Singh MP, Pathak K, Animal models for biological screening of anti-diabetic drugs: An overview.Eur J Exp Biol 2015;5(5):37-48
2. Kujur RS, Singh V, Ram M, Yadava HN, Singh KK, Kumari S, Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats.Pharmacogn Res 2010;2(4):258-63
3. Raval K, Ganatra T, Basics, types and applications of molecular docking: a review.Int J Compr Adv Pharmacol 2022;7(1):12-8
4. Karthikeyan M, Balasubramanian T, Kumar P, In-vivo Animal Models and In-vitro Techniques for Screening Antidiabetic Activity. .J Dev Drugs 2016;5:153
5. Raval K, Tirgar P, Patel M, Desai T, Preclinical Evaluation of Neuroprotective Activity of Piper nigrum L. in Cerebral Ischemic Reperfusion Induced Oxidative Stress.Chettinad Health City Medical Journal 2022;11(2):33-40