Role of biologic modifiers in periodontal regeneration- A review

Abstract

Regenerative techniques, which aim to replace damaged periodontal ligament, bone, cementum, and connective tissue, are newer approaches to periodontal care. In periodontology and oral implantology, the development of molecular mediators has accelerated substantially over the last decade. At various cellular levels, different growth agents cause distinct reactions in periodontal tissues. The potency of biologics in regenerating the periodontal tissues is the call attention in this review paper, in which it discusses the structure, mechanism of action, indication and FDA (Food and Drug Administration) approval to use in regenerating periodontal tissues. The working activity of biologic agents together with reasons for utilizing them in regenerating tissues of periodontium lost due to disease are discussed, as well as the expected benefits as compared to traditional approaches.