Interrelationship between Gut microbiota and Parkinson’s disease

Abstract

Neurological outcomes like learning, memory and cognition are influenced by the gut microbiota (GM). These commensal GM modulates behavior and brain development and has implications in many neurological disorders like Alzheimer’s disease, Parkinson’s disease (PD), anxiety, stress, multiple sclerosis, etc. PD is a neurodegenerative disease which causes dysbiosis, α-synucleinopathy and affects the gut-brain axis which includes CNS (Central nervous system), ANS (Autonomic nervous system) and ENS (Enteric nervous system). There is a bidirectional communication between the brain and the gut called “gut microbiota-brain axis (GMBA)” and its dysfunction causes numerous diseases. This review focuses on the inter-relationship between the gut microbiome and the Parkinson’s disease.