Affiliation:
1. Oral Surgery Service, , Senegal
2. O
Abstract
The aim of the present study was to investigate the Ki67 expression level and to measure the cell proliferation index (Ki67) in odontogenic benign tumors.This was an analytical cross-sectional study of odontogenic benign tumors. The sampling was non-probabilistic with an exhaustive recruitment including all biopsy or surgical excision specimen of odontogenic benign tumors. Ki67 immunohistochemistry was performed on histological sections of paraffin-fixed tissues of 3µ thickness with the Ki67 (MM1) monoclonal antibody. The studied variables were sociodemographic, clinical and histopathological. The data have been analysed with SPSS 20.0 software.: Ameloblastoma represented 50.9% of cases and cemento-osseous dysplasia 36.4%. Among the 28 ameloblastoma cases, the 15 (53.6%) were plexiform type, the 7 (25%) follicular type and the 6 (21.4%) unicystic type. The percentage of Ki67 labelled cells was less than 1% in 74.6% (n=41) of the tumors and was equal to 5% in 12.7% (n=7) of cases. A Ki67 law labelling was found in 87.3% (n=48) of tumours and a negative labelling in 12.7% (n=7) of cases. The odontogenic benign tumors had a weak Ki67 expression level and a low epithelial cell proliferation index. The Ki67 could not therefore be used as a predictive biomarker of tumor cell proliferation and the risk of recurrence in odontogenic benign tumors.
Publisher
IP Innovative Publication Pvt Ltd
Reference27 articles.
1. Menditti D, Laino L, Domenico MD, Troiano G, Guglielmotti M, Sava S, Cysts and Pseudocysts of the Oral Cavity: Revision of the Literature and a New Proposed Classification.In Vivo 2018;32(5):999-1007
2. Dubrulle F, Martin-Duverneuil N, Maxillofacial tumor pathology in adults.Imagerie cervico-faciale .43-52
3. Abdennoura S, Benhalima H, Benign odontogenic tumors: epidemiological analysis of 97 cases in the Algerian population.Rev Stomatol Chir Maxillofac Chir Orale 2013;114(2):67-71
4. Alsaegh MA, Miyashita H, Taniguchi T, Zhu SR, Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma.Exp Ther Med 2017;13(1):247-53
5. Nagi R, Sahu S, Rakesh N, Molecular and genetic aspects in the etiopathogenesis of ameloblastoma: An update.J Oral Maxillofac Pathol 2016;20(3):497-504