From epidemic to pandemic covid-19 world crisis!

Abstract

There is a new public health crises threatening the world with the emergence and spread of 2019 novel corona virus (2019-nCoV) The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China in December 2019.It caused a total of 80,868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. According to the current pandemic situation the worldwide report of death due to COVID-19 is 165,877,654, cases confirmed and 3,445,463 death and 146,583,420 recovered. The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. The disease is mild in most people; in some, usually the elderly and those with comorbidities, it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi organ dysfunction. As COVID-19 has triggered enormous human casualties and serious economic loss posing global threat, an understanding of the ongoing situation and the development of strategies to contain the virus's spread are urgently needed. Currently, various diagnostic kits to test for COVID-19 are available and several repurposing therapeutics for COVID-19 have shown to be clinically effective. In addition, global institutions and companies have begun to develop vaccines for the prevention of COVID-19. Here, we review the current status of epidemiology, diagnosis, treatment, and vaccine development for COVID-19.