Microelectrode recordings (MER) signals with subthalami nucleus (STN) deep brain stimulation (DBS) local field potentials (LFP) in basal ganglion circuitry in Parkinsonians

Abstract

Since last 10 years, the authors have established what seems designate a extremely effective phenomenological model-prototype for evaluating the D B S in alleviating symptoms of Parkinson disease (PD). In this study, we broaden the scope of the model applying it to predict the computation and then generating more frequencies as of net-works (NW) tuned to a particular frequency, in fact not an self - oscillatory in any way. Two main issues discussed, 1. basic and fundamental systems are connected (or coupled) in an excitatory vogue, that is designated by ‘+ / +’, 2. Where the basic/constituent systems are connected in excitatory-inhibitory way, designated by ‘+ / -’. It expects that as of a ‘basic-system’ tuned-to tremor-frequency such that we can compute/ generate infinite (limitless) range-of-frequencies. Our example specifically, start as of systems that are primarily non oscillatory, which while the connecting coefficient surpasses a certain/threshold-value, the system starts to oscillate by the signal-amplitude that enhances through he connecting/‘coupling-strength’. One more feature-manifestation, that shown to rise by connecting complex net-works based on physiology of basal-ganglia(BG) be exemplified through “root-locus” strategy method that displays enhancing plus reducing oscillatory frequencies, present concurrently, has the theory which their symmetrical average-mean leftovers/remnants significantly continuous as the connecting-strength(amplitude) is speckled. Through this method, we are offering a new utility-tool to comprehend reality also interface of “pathological-oscillations” that trigger, PD plus more ailments ex. Memory, cognition, cognitive-impairment (CI), cognitive dementia (CD), depression, epileptic-seizures, Tourette’s syndrome, Huntington’s disease, and axial symptoms like speech, hallucinations, and gait.