Clinical profile of patients with acute ischaemic stroke undergoing thrombolysis in a tertiary hospital- A retrospective observational study

Abstract

Acute ischaemic stroke is one of the most important causes of morbidity and mortality in the Indian subcontinent. Intravenous thrombolysis has revolutionized the treatment of acute stroke and has shown good evidence of its efficacy in most patients. The primary objectives of the study were to study the clinical and demographic profile of stroke patients undergoing intravenous thrombolysis and to determine their functional outcome after three months. The study was done by retrospective chart analysis of all patients with acute stroke in Neurology department undergoing intravenous thrombolysis over a one year period. Primary outcome was measured by assessing the Modified Rankin Scale after three months.A total of 56 patients underwent intravenous thrombolysis in the study period of which 68 percent were males. The average age of the study population was 62.4 years. The most common co- morbidities noted were hypertension followed by dyslipidemia, type 2 diabetes mellitus, coronary artery disease and chronic kidney disease among others. The average duration of the window period and door to needle time were 148.4 minutes and 66.3 minutes respectively. Intracranial haemorrhage was noted in seven patients (12.5%) of which six expired. Favourable outcome defined by MRS score of 0-2 was achieved in almost 68% of all patients undergoing thrombolysis.Intravenous thrombolysis is an effective mode of treatment for acute stroke with favourable outcomes obtained in the majority of patients undergoing the same.