Attenuation of sympathoadrenal response to direct laryngoscopy and intubation using 0.25mg/kg injection labetalol

Abstract

: Direct laryngoscopy and endotracheal intubation evokes autonomic disturbances in the form of tachycardia, raise in blood pressure, intracranial, and intraocular pressure.Thus the present study was undertaken to evaluate the efficacy of injection Labetalol 0.25mg/kg body weight in the attenuation of sympathoadrenal response to direct laryngoscopy and endotracheal intubation.: The study was conducted on 60 participants belonging to ASA grade 1 or 2 aged between 18 – 55 yrs undergoing elective surgeries under general anaesthesia. The study population was randomly divided into 2 groups with 30 subjects in each group.Group LAB (Labetalol group) – received 0.25mg/kg body weight diluted upto 10ml with normal saline intravenously, over 10minutes using a syringe pump, given 10minutes before induction.Group CR (Control) received 10ml of normal saline intravenously.The study drug was administered over 10 minutes using syringe pump followed by induction with inj Thiopentone 5mg/kg body weight and inj vecuronium 0.1mg/kg body weight three minutes prior to laryngoscopy and intubation. HR(Heart rate), Systolic arterial pressure, diastolic arterial pressure, MAP(mean arterial pressure) were recorded at basal, 2 minutes, 5 minutes, 8 minutes after study drug infusion, before induction, after induction, 1, 2, 3, 5, 10, 15 minute after laryngoscopy and intubation.: The result showed statistically significant (p<0.05) decrease in Heart rate, Systolic arterial Pressure, Diastolic arterial pressure and Mean arterial pressure in Group LAB compared to Group CR at all the time intervals.In the present study, it was found that inj Labetalol 0.25mg/kg body weight had effectively attenuated the sympathoadrenal response to laryngoscopy and intubation.