Intraperitoneal local anesthetic instillation as a method to attenuate pneumoperitoneum induced hemodynamic response during laparoscopic surgeries: A randomized placebo controlled study

Abstract

Laparoscopy is associated with significant hemodynamic changes due to pneumoperitoneum creation. We sought to study the effectiveness of intraperitoneal local anesthetic instillation in attenuating pneumoperitoneum-mediated hemodynamic response in patients undergoing laparoscopic cholecystectomy. This randomized study was conducted after approval from the institutional ethics committee, and 100 patients were randomly assigned to either group R (40 mL of 0.2% Ropivacaine intraperitoneally) or group N (40 mL of 0.9% normal saline intraperitoneally). Data analysis was performed using SPSS version 23. Independent Samples T test was used to compare hemodynamic variables between groups at regular intervals. Statistical significance was set less than 0.05.: Heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure were significantly lower in Group R than in Group N at 15,30, 45,60,75, and 90 min (P<0.05).: Intra peritoneal instillation of 0.2% Ropivacaine in laparoscopic cholecystectomy attenuates intra operative hemodynamic changes associated with pneumoperitoneum.