Injection with long chain triglyceride or long chain triglyceride/medium chain triglyceride propofol: Which is less painful?

Abstract

: Long chain triglyceride/Medium chain triglyceride (LCT/MCT) Propofol 1% suspension is a new formulation having 10% fat emulsion consisting of long chain triglycerides (LCT) and medium-chain triglycerides (MCT). The pharmacokinetics and efficacy are similar to the standard Propofol LCT. To compare incidence, intensity of pain on injection and hemodynamic stability with both 1% Propofol -LCT and 1% Propofol-LCT/MCT in patients undergoing surgery with general anaesthesia. : This was a comparative study conducted in Shri M.P. Shah Medical College and Guru Gobind Hospital, Jamnagar. After due ethical clearances, 60 patients were divided into L group and L/M group by using random number table after taking written informed consent. The L-Group received 1% propofol-LCT while the L/M group received 1% propofol-LCT/MCT. After induction, pain was assessed using Verbal Rating Score for incidence and intensity of pain. In L-group, 29 (96.67%) patients complained of pain, while in L/M-group 24 (80%) patients perceived pain. Ten (33.3%) patients in L group and 18 (60%) in L/M group had none to mild pain, but moderate to severe pain was perceived by 20 (66.67%) patients in L group compare d to 12(40%) in L/M group. The incidence of pain and intensity of pain on injection was greater in group L (p=0.04 and 0.03 respectively).: Propofol-LCT/MCT may be considered in place of propofol-LCT as an anaesthetic agent since it reduces pain of injection.