A comparative study of intrathecal morphine v/s nalbuphine along with bupivacaine in laparoscopic gynaecological procedures

Abstract

: To compare the pain score of intrathecal morphine v/s nalbuphine along with bupivacaine in laparoscopic gynaecological procedures under general anaesthesia.: A prospective, comparative, randomized, double blinded, hospital based study was conducted among patients undergoing elective laparoscopic gynaecological procedures. After explaining the study to the selected patients, they were randomized into two groups of 30 each with the use of sealed envelope method i.e. group M (100 µg morphine + 2 ml bupivacaine) and group N (400 µg Nalbuphine + 2 ml bupivacaine). The primary objective of our study was to compare the pain intensity which was done by visual analogue scale (VAS). Any side-effects in the form of post-operative hypotension, bradycardia, respiratory depression, nausea, vomiting and pruritus were recorded and included as secondary objectives. With the help of SPSS version 24, difference between the continuous and categorical variables was analysed using t and chi square test respectively.: There was no significant difference among both groups with respect to motor blockade score. Mean VAS after extubation and 3 hour was comparable among both the groups, but at 6, 12 and 24 hour, it was comparatively more in group N as compared to group M, though statistically insignificant. Pruritus was revealed in 10% and 0% of the subjects among group M and N respectively. : Our results conclude that the analgesic efficacy of nalbuphine is comparable to morphine, but nalbuphine provides a better safety profile than morphine especially related to pruritus.