Comparison of intravenous granisetron and intravenous lignocaine to alleviate pain on propofol injection: A double blind, randomized, controlled trial

Abstract

The objective of the study was to compare effectiveness of intravenous (IV) granisetron (2 milligram) with IV lignocaine (30 milligram) in allaying pain on propofol IV administration measured at 15 seconds after propofol administration. 100 patients of age 18-50 years belonging to American Society of Anesthesiologists (ASA) physical status grades I and II, chosen for elective surgery were randomized to two different groups (group L and group G) of 50 each. Patients of group L received IV lignocaine 30 mg and the other group G received IV granisetron 2 mg as pretreatment, before administration of propofol. Patients were assessed for pain after 15 seconds of IV administration of propofol with McCririck and Hunter scale. Both the pretreatments were found to prevent or decrease the pain on propofol administration. Pain assessed at the end of 15 seconds of propofol administration, showed that 76% in lignocaine group & 62%in granisetron group were not having any pain, 12% in lignocaine group and 20% in granisetron group had mild pain, and 12% in lignocaine group and 18% in granisetron group had moderate pain as assessed with McCririck and Hunter scale. There was no significant difference in the pain scores between the groups (χ2 = 2.310, P= 0.315). Both IV granisetron (2 mg) and IV lignocaine (30 mg) are equally effective in allaying pain on propofol injection.