To evaluate the efficacy between 0.15mg/Kg and 0.25mg/Kg of iv labetalol in the suppression of haemodynamic response to extubation

Abstract

Tracheal extubation process evokes stress response which causes autonomic variations such as tachycardia, rise in systolic arterial blood pressure and diastolic arterial blood pressure which is potentially lethal in high risk patients.Thus this study is conducted to compare the efficacy between 0.15mg/kg and 0.25mg/kg of iv Labetalol in the suppression of haemodynamic response to Extubation. 60 participants aged between 18-55 yrs belonging to ASA 1 or 2 were randomly allocated into 2 groups. Group Lb received injection Labetalol 0.15mg/kg and Group Lt received injection Labetalol 0.25mg/kg. Heart rate, systolic arterial blood pressure and diastolic arterial blood pressure were recorded at basal, two, five, eight minutes after drug infusion, at extubation and one, three, five, eight, ten and fifteen minutes post extubation. Group Lt showed a better lowering values in heart rate, systolic arterial blood pressure and diastolic arterial blood pressure after drug infusion, at Extubation, and fifteen minutes post Extubation compared to Group Lb. Injection Labetalol 0.25mg/kg showed a effective suppression of haemodynamic response to Extubation compared to injection Labetalol 0.15mg/kg.