Benign germ cell tumour and epithelial carcinoma – Rare synchronous presentation in unilateral ovary on background of endometriosis

Abstract

Ovarian carcimomas are the second most common gynecological malignancy of which more than 90% arise from surface epithelial cells. Endometriosis-related ovarian neoplasms (ERONs) are described as a group of tumors which include clear cell carcinoma, endometrioid carcinoma, and seromucinous borderline tumor. Benign cystic teratomas are commonest benign ovarian neoplasms derived from germ cells. Coexistence of benign cystic teratoma, endometrioid adenocarcinoma and clear cell carcinoma in the same ovary is very unusual. Our case presented with well differentiated endometrioid adenocarcinoma grade 2 with squamous metaplasia and a nodule of clear cell carcinoma on the background of endometriosis and benign cystic teratoma in the same ovary. To the best of our knowledge, this is the first case with such an unusual combination to be reported in the medical English literature.