A study of histomorphological features of fallopian tube and immunohistochemical stains for p53 & ki67 of the fimbrial end of fallopian tube

Abstract

: Fallopian tube is the origin of ovarian cancer especially high grade serous carcinoma. Precursor lesion of ovarian cancers in the fallopian tube now recognized includes p53 signature, secretory cell outgrowth (SCOUT), tubal intraepithelial lesion in transition (TILT) and serous tubal intraepithelial lesion (STIC) through histomorphological features and by using immunohistochemical staining for p53 and ki67. This study emphasizes in detection of precursor lesion in fallopian tube in all resected fallopian tube submitted in the department during the study period. Ability to detect precursor lesion would have profound impact on preventive strategies of ovarian cancer and modalities of management of the disease in the initial stages that ultimately help in reducing the disease burden and increasing overall survival rate. : To determine the histomorphologiscl features of fallopian tube and to assess the evidence of precursor lesions in fallopian tube epithelium using immunohistochemistry stain p53 and ki67.: The study was carried out in the department of pathology in collaboration with the department of obstretics and gynecology, regional institute of medical sciences. Study was conducted for two years from September 2018 to August 2020. All the fallopian tubes specimen received during the study period were included in the study except those specimen with damaged, autolyesd, of post radiation therapy and post chemotherapy patients. A total of 120 specimen were collected. A total of 120 samples were included in the study. Mean age of the participants was 47 years with a minimum age of 24 years and maximum age of 72 years. 56. 7 % of the participants were in post menopausal age group. Out of the 120 cases only 12 cases (10 %) showed p53 signature and one case (0.8%) showed presence of STIC.: Only one case of STIC was detected in the fallopian tube where the ovary had High grade serous carcinoma. Few cases showed for p53 signature evident by using IHC p53 and ki67 which is more frequent in corresponding ovarian pathology than uterine pathology.