STRING analysis of beta-lactamase in : Identification and characterization of predicted functional partners

Abstract

This study investigates the functional roles and predicted interactions of the putative beta-lactamase STY4057 in using STRING database analysis. is a pathogenic bacterium responsible for typhoid fever, presenting significant public health challenges. We identified several key functional partners of STY4057 by exploring various interaction criteria, including gene fusion, co-occurrence, co-expression, and experimental data through STRING database analysis. The analysis revealed interactions with regulatory proteins, metabolic enzymes, and proteins involved in adhesion and biofilm formation. High-confidence interactions with STY4058 (a regulatory protein) and apeE (an outer membrane esterase) suggest significant roles in transcriptional regulation and lipid metabolism. The findings underscore the potential contribution of STY4057 to antibiotic resistance and pathogenicity in . Interactions with regulatory proteins like STY4058 may influence beta-lactamase expression, while interactions with metabolic enzymes like apeE could affect membrane permeability and antibiotic influx, providing insights into s survival and resistance mechanisms.: This study lays the groundwork for future experimental validation and therapeutic target development, offering insights into s survival and resistance capabilities. Further research is needed to validate these interactions and explore their potential as therapeutic targets.