Induction of labour with oral misoprostol solution 20 microgram versus vaginal misoprostol 25 microgram 6th hourly

Abstract

Induction of labour is the artificial initiation of labour before the spontaneous onset, and it is the common obstetric intervention. To compare the potency of oral misoprostol solution with vaginal misoprostol to induce labour at term. This randomized control study was carried out from July 2020 to September 2020 at Government General Hospital, Kakinada. : 80 women requiring induction were recruited in the study. The women were randomized to receive 20 micrograms of oral misoprostol solution every 2 hourly or vaginally 25 micrograms of misoprostol every 6 hourly until the labour sets in the active phase of labour. Delivery within 24 hours was the outcome in the study. Data were documented in Microsoft excel and analyzed using SPSS software. : 82.5% of women in the oral group delivered by spontaneous vaginal delivery, whereas 75% in the vaginal group. In the oral group, 37.5% of delivery occurred within 6-12 hours, 40% delivered within 12-18hours duration, whereas in the vaginal group, 12.5% delivered within 6-12hours duration, 50% delivered within 12-18hours duration. Oxytocin augmentation was required in 25% of the oral group, whereas 42.5% in the vaginal group. Meconium stained liquor was 12.5% in the oral group, whereas 20% in the vaginal group.12.5% underwent cesarean section in the oral group, 10% in the vaginal group. Compared with vaginal misoprostol, oral misoprostol solution results in shorter induction delivery interval and less oxytocin augmentation required.