To evaluate histopathological changes in placenta of IUGR

Abstract

The present study entitled “To evaluate Histopathological changes in Placenta of IUGR” was conducted in the Department of Obstetrics and Gynaecology. A total of 400 patients were studied. Out of them 200 were normal patients without IUGR and 200 with IUGR. These patients were evaluated with the help of semistructured proforma consisting of various socio-demographic and clinical variables.Number of LSCS deliveries in IUGR patients (59) is significantly more than control group (33).The number of syncytial knot formation (>10) in IUGR is 169 compared to 153 of control and hence is statistically insignificant. Cytotrophoblastic proliferation (>10) in IUGR (126) is significantly more than (92) in the control group. Number Of area fibrinoid necrosis in villi > 5 in IUGR group is 57 compared to control group (29) (significantly higher) No. of hylinized areas (> 5) in IUGR (101) is significantly higher than in control group (68). Histopathological findings in low power field like syncytial knot formation, cytotrophoblastic cellular proliferation, calcification and hyalinisation of villi are also found as normal aging changes in placenta but it occur early and more frequently per low power field in IUGR group. To conclude, these morphological & histological findings of placenta are the etiological basis for Intra uterine growth restriction.