Comparision of intravenous iron sucrose and intravenous ferric carboxymaltose for treatment of iron deficiency anemia in pregnant women: in a tertiary care hospital in Chengalpattu district

Abstract

Anaemia is the most common manageable problem among pregnant women worldwide, which contribute to maternal and perinatal mortality.The aim is to compare the efficacy, safety and compliance of intravenous ferric carboxymaltose with intravenous iron sucrose in the treatment of iron deficiency anaemia in pregnancy. It is a randomized prospective study conducted in department of obstetrics and Gynecology at Shri Sathya Sai Medical College, constituting of 100 pregnant women. 50 pregnant anemic patients were treated with intravenous ferric carboxymaltose and other 50 patients were treated with intravenous iron sucrose. Hemoglobin, packed cell volume and blood indices were measured before and 3 weeks after treatment. The efficacy and safety of both intravenous compounds were studied.Anaemia in pregnancy was more prevalent among 20-24 years of age groups, it is more common in multigravida in 22-28 weeks of gestational age. The mean difference of hemoglobin 3 weeks after treatment was 2.34 g/dl for ferric carboxymaltose and 1.32g/dl for iron sucrose. The other parameters also increased significantly for ferric carboxymaltose than iron sucrose.: ferric carboxymaltose is an efficient and better alternative in iron deficiency anaemia in pregnancy with fewer side effects and has the added advantage of single dose regime.