Efficacy of tablet metronidazole and clindamycin in management of bacterial vaginosis in a tertiary care hospital in Chengalpattu district

Abstract

BV is a common disorder, yet poorly understood poly-microbial vaginal infection. It is more commonly seen in women in reproductive age group. It has high prevalence in African women specially those in sub-Saharan Africa. Approximately 50-69% of women with BV are not symptomatic and women who presents with symptoms varies from Gray-white offensive vaginal discharge intensified after sexual intercourse and during menstruation, lower abdominal pain and dyspareunia. BV is diagnosed by two different criteria such as Amsel’s and Nugent’s. After the diagnosis according to the above criteria, CDC & ACOG recommended either orally or Intravaginally Metronidazole or Clindamycin is given to treat BV. To study the effectiveness of Clindamycin on Bacterial Vaginosis and compare with commonly used Metronidazole. A randomized control study was done after approval from Institute Ethical committee on patients who came to Gynaecology OPD in Shri Sathya Sai Medical College and Research Institute after taking written and informed consent.All study subjects were examined in the OPD. Under aseptic precautions a high vaginal swab was taken and sent to microbiology lab for culture and sensitivity and using the criterias mentioned below such as Amsel’s and Nugent’s, diagnosis will be noted and treated accordingly.Clindamycin is better than Metronidazole with respect to Amsel’s criteria and Nugent’s after treatment (P<0.05) and with respect to the culture results after treatment (P<0.05).Oral Clindamycin may be preferable to Oral Metronidazole because of its broader spectrum of activity.