Study of metabolic syndrome in south Indian PCOS women

Abstract

PCOS is one of the common endocrine disorders in women leading to various complications like infertility, menstrual, psychological disturbances and metabolic syndrome. The objectives of this study were to study the clinical and biochemical parameters of metabolic syndrome in women of reproductive age group with PCOS. This cross-sectional study was conducted in a tertiary care centre from September 2018 to June 2020. Fifty six women diagnosed with PCOS, underwent clinical and laboratory assessments for the diagnosis of metabolic syndrome, as per international diabetes federation (IDF) criteria. 14.3% subjects had metabolic syndrome. The prevalence of individual components of the metabolic syndrome among PCOS patients were: waist circumference >80cms in 100%, HDL < 50mg/dl in 100%, triglycerides > 150mg/dl in 75%, blood pressure >130/85mmhg in 12.5%, fasting plasma glucose > 100 mg /dl in 87.5%. Subjects with metabolic syndrome had significantly higher BMI compared to those without metabolic syndrome (p=0.043). The metabolic syndrome and its individual components, like waist circumference and decreased HDL were found to be more common among PCOS patients in this study. As the risk of MetS increases with age and BMI, early screening and timely interventions like lifestyle changes will prevent metabolic complications like cardiovascular diseases and type II diabetes mellitus.