A randomised double blind clinical study on effect between clomiphene citrate plus metformin and clomiphene citrate alone on induction of ovulation in women with polycystic ovarian syndrome

Abstract

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age-group, characterised by a combination of hyperandrogenism, chronic anovulation, and polycystic ovaries. It is one of the most common cause of hyperandrogenism, hirsutism and anovulatory infertility. The aim of the study is to determine & compare the rate of ovulation, regularisation of menstrual cycle and rate of pregnancy by use of combination of Clomiphene citrate and Metformin & with use of Clomiphene citrate alone in patients with PCOS.A total 110 patients (55 in each group) having primary subfertility and diagnosed as PCOS in age group of 18 to 40 years of age, selected between April 2017 – March 2018. The primary outcome i.e, incidence of ovulation was detected by folliculometry. The secondary outcomes, i.e, regularisation of menstrual cycle & Pregnancy rates were taken into account and compared in both the groups.Overall ovulation was found highest at the end of 3rd cycle of ovulation induction, 48.8% and 41% respectively in each group. The Primary outcome was significantly higher in group a given combination of clomiphene citrate and metformin (83.3%) with respect to group B given clomiphene citrate only (65.9%). The secondary outcomes were significantly higher in group given CC plus metformin (89.6%). Pregnancy rates were higher in 1st group 33.3% than 2nd group (20.5%).In the present study one group was given combination of Clomiphene citrate with metformin and another group was given clomiphene citrate only for ovulation induction. It was found that combination of clomiphene citrate and metformin was more effective in induction of ovulation in women suffering from PCOS when compared to induction of ovulation with clomiphene citrate alone.