The Concordance between Cytological and Histological Specimens of Bile Duct and Malignancy Rates of Cytological Specimens: A Study in a Single Institution

Author:

Abstract

Background: Cytological evaluation of biliary tract specimens, especially from the common bile duct, is a procedure to identify potential malignant lesions that is less invasive than resection. Staffs of cytological service examined cytological specimens from the bile duct. Following this, tissue biopsy or resection was conducted and the diagnostic discrepancies between the two procedures were analyzed. Objective: To investigate the diagnostic concordance rates from the histological and the cytological examination of bile duct specimens and to evaluate the malignancy rate according to the bile duct cytological diagnostic category. Materials and Methods: Seventy-eight cytological bile duct specimens were collected between January 2011 and September 2017. In addition, 44 histological biopsied or resected specimens were retrospectively included in the present study. The Kappa coefficient was calculated and used to determine the concordance rate between the two procedures. The sensitivity and positive predictive value of cytology were calculated and compared to histological biopsied or resected specimens. The malignancy rates among the cytological diagnostic categories were identified. Results: There was moderate concordance between the cytology and the biopsy or resected specimens (K=0.52, p=0.001), the sensitivity and specificity of which were 75% (95% CI 47.62 to 92.73) and 79% (95% CI 59.05 to 91.70), respectively. The positive predictive value was 67 (95% CI 48.24 to 81.10), and negative predictive value was 85% (95% CI 69.73 to 92.92). The malignancy rate in the negative for malignancy group was 18%. Conclusion: The diagnostic concordance rate between the cytological results of bile duct specimens and the results of biopsy or resection was 77% (95% CI 62 to 88), with a moderate concordance rate (K=0.52, p=0.001). Keywords: Bile cytology, Bile duct, Cytology, Histology, Concordance rate, Bile duct cancer

Publisher

Medical Association of Thailand

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3