A Decade of Risk Factors in Cerebral Palsy: A Retrospective Review at Thammasat University Hospital, Thailand

Abstract

Background: Cerebral palsy (CP) causes patients to experience developmental delays, affecting self-help. CP has many risk factors, unfortunately, no total risk summarization exists now. Objective: To study the risk factors for neonate CP, making it possible to diagnosis early and reduce complications. Materials and Methods: The present study was a retrospective case control study in children aged 0 to 2 years, born at Thammasat University Hospital, Thailand between 2005 and 2014. Multivariable logistic regression compared perinatal period risks between normal children (control) and those with CP (case). Results: Within the multivariable logistic regression evaluation, CP risk factors were cerebral and non-cerebral malformations, low birthweight, neonatal sepsis, with adjusted odds ratio 250.43, 16.04, 32.60, and 63.15, respectively. Conclusion: Cerebral and non-cerebral malformations, low birthweight, and neonatal sepsis are CP predictive risks. However, multi-fetal gestation, preterm birth, low Apgar score, fetal distress, uterine and cord anomalies, maternal infection, neonatal seizure, neonatal encephalopathy, congenital infections, and use of ventilator remain undetermined. A multicenter research incorporating the other events is needed. Keywords: Cerebral palsy, Risk factors, Prenatal, Perinatal, Postnatal