AcrTransAct: Pre-trained Protein Transformer Models for the Detection of Type I Anti-CRISPR Activities

Author:

Hasani Moein1ORCID,N. Trost Chantel2ORCID,Timmerman Nolen1ORCID,Jin Lingling1ORCID

Affiliation:

1. Computer Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

2. Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

ACM

Reference31 articles.

1. UniProt: the universal protein knowledgebase

2. Joe Bondy-Denomy , April Pawluk , Karen L Maxwell , and Alan R Davidson . 2013. Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Nature 493, 7432 ( 2013 ), 429--432. Joe Bondy-Denomy, April Pawluk, Karen L Maxwell, and Alan R Davidson. 2013. Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Nature 493, 7432 (2013), 429--432.

3. Stan JJ Brouns , Matthijs M Jore , Magnus Lundgren , Edze R Westra , Rik JH Slijkhuis , Ambrosius PL Snijders, Mark J Dickman, Kira S Makarova, Eugene V Koonin, and John Van Der Oost. 2008 . Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 321, 5891 (2008), 960--964. Stan JJ Brouns, Matthijs M Jore, Magnus Lundgren, Edze R Westra, Rik JH Slijkhuis, Ambrosius PL Snijders, Mark J Dickman, Kira S Makarova, Eugene V Koonin, and John Van Der Oost. 2008. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 321, 5891 (2008), 960--964.

4. Structure reveals mechanisms of viral suppressors that intercept a CRISPR RNA-guided surveillance complex;Chowdhury Saikat;Cell,2017

5. Anti-CRISPRdb: a comprehensive online resource for anti-CRISPR proteins;Dong Chuan;Nucleic Acids Research,2018

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