Image Processing Pipeline to Compute Homologous Recombination Score

Author:

Vundavilli Haswanth1,Tumiati Manuela2,Hautaniemi Sampsa2,Datta Aniruddha3,Kauppi Liisa2

Affiliation:

1. Texas A&M University, USA and The University of Texas MD Anderson Cancer Center, USA

2. Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Finland

3. Department of Electrical and Computer Engineering & The Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, USA

Funder

NSF (National Science Foundation)

Academy of Finland

European Union's Horizon 2020

TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering (CBGSE)

Publisher

ACM

Reference12 articles.

1. Platinum compounds: a hope for future cancer chemotherapy;Ali I., A;Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents),2013

2. Fuchs R.P. 2002. How DNA lesions are turned into mutations within cells?. Oncogene 21(58). Fuchs R.P. 2002. How DNA lesions are turned into mutations within cells?. Oncogene 21(58).

3. da Cunha Colombo Bonadio , R.R. , Fogace , R.N. , Miranda , V.C. and Diz , M.D.P . E ., 2018 . Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management. Clinics , 73. da Cunha Colombo Bonadio, R.R., Fogace, R.N., Miranda, V.C. and Diz, M.D.P.E., 2018. Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management. Clinics, 73.

4. Wiedemeyer W.R. Beach J.A. and Karlan B.Y. 2014. Reversing platinum resistance in high-grade serous ovarian carcinoma: targeting BRCA and the homologous recombination system. Frontiers in oncology 4 p.34. Wiedemeyer W.R. Beach J.A. and Karlan B.Y. 2014. Reversing platinum resistance in high-grade serous ovarian carcinoma: targeting BRCA and the homologous recombination system. Frontiers in oncology 4 p.34.

5. Telli M.L. Timms K.M. Reid J. Hennessy B. Mills G.B. Jensen K.C. Szallasi Z. Barry W.T. Winer E.P. Tung N.M. and Isakoff S.J. 2016. Homologous recombination deficiency (HRD) score predicts response to platinum-containing neoadjuvant chemotherapy in patients with triple-negative breast cancer. Clinical cancer research 22(15) pp.3764-3773. Telli M.L. Timms K.M. Reid J. Hennessy B. Mills G.B. Jensen K.C. Szallasi Z. Barry W.T. Winer E.P. Tung N.M. and Isakoff S.J. 2016. Homologous recombination deficiency (HRD) score predicts response to platinum-containing neoadjuvant chemotherapy in patients with triple-negative breast cancer. Clinical cancer research 22(15) pp.3764-3773.

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