Maple application for structural identifiability analysis of ODE models

Author:

Ilmer Ilia1,Ovchinnikov Alexey2,Pogudin Gleb3

Affiliation:

1. CUNY Graduate Center

2. CUNY Queens College

3. LIX, CNRS, Paris, France

Abstract

Structural identifiability properties of models of ordinary differential equations help one assess if the parameter's value can be recovered from experimental data. This theoretical property can be queried without the need for data collection and is determined with help of differential algebraic tools. We present a web-based Structural Identifiability Toolbox that rigorously uncovers identifiability properties of individual parameters of ODE systems as well as their functions (also called identifiable combinations) using the apparatus of differential algebra. The application requires no installation and is readily available at https://maple.cloud/app/6509768948056064/

Publisher

Association for Computing Machinery (ACM)

Reference16 articles.

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2. Computing representations for radicals of finitely generated differential ideals;Boulier F.;Applicable Algebra in Engineering, Communication and Computing,2009

3. Structural Identifiability of Systems Biology Models: A Critical Comparison of Methods;Chiş O.-T.;PLoS ONE,2011

4. Dynamics of Posttranslational Modification Systems: Recent Progress and Future Directions;Conradi C.;Biophysical Journal,2018

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