Posaconazole Loading and Release Behavior in Surface-Modified Mesoporous Silica Nanoparticular System

Abstract

In conventional drug treatments, high toxic effects, low solubility, and low bioavailability of the active substance cause insufficient drug release in the target tissue and undesirable side effects in healthy tissue. Various drug delivery systems are utilized to eliminate these undesirable effects. Mesoporous silica nanoparticles (MSN) are biocompatible biomaterials that have a large surface area, high pore volume, and enhanced adsorption capacity. With MSN-mediated controlled drug release, the active substance concentration in the blood is kept within the desired therapeutic range. Posaconazole (PCZ) is an antifungal agent. Absorption of PCZ is difficult due to its low solubility in aqueous and acidic environments, low therapeutic effect and low bioavailability. The use of controlled drug release systems avoids these problems and facilitates the absorption and release of PCZ. In this study, it is aimed to enhance the PCZ adsorption and release by using a drug delivery system. MSNs were synthesized by sol-gel method, and surface modification of nanoparticles was achieved using (3-Aminopropyl) triethoxysilane (APTES). PCZ was loaded on APTES-modified MSN successfully. MSN, APTES-modified MSN and PCZ loaded APTES-modified MSN were characterized. Diffusion controlled release of PCZ was observed in drug release studies.