Can platelet distribution width lymphocyte ratio be a novel biomarker for predicting survival in metastatic renal cell cancer?

Abstract

Aim: The prognostic value of platelet distribution width to lymphocyte ratio (PDWLR) in patients with metastatic renal cell cancer using tyrosine kinase inhibitors is not clearly known. Our aim in this study is to evaluate the prognostic importance of PDWLR in patients with metastatic renal cancer. Meterial and results: This retrospective study included 66 patients with metastatic renal cell cancer who were currently receiving Tyrosine kinase inhibitor treatment between January 2010 and December 2020. The cut off value was determined by ROC curve analysis. The best cut-off value for RDWLR was determined as 9.33. Sensitivity and specificity for RDWLR were 55.3% and 57.9%, respectively. Chi-square and Fisher exact tests were used to evaluate the relationship between PDWLR and clinicopathological variables. Cox proportional hazards model was used for multivariate analysis. Conclusion: It has been determined that PDWLR measured during treatment in metastatic RCC patients using TKIs has no significant effect on Pfs, which is an important prognostic factor in predicting OS. In patients with metastatic renal cell cancer, PDWLR level can be used as a prognostic marker, but studies with a larger number of patients are needed.