The Relationship Between Serum Visfatin Levels and Metabolic Parameters According To Different Body Mass Indexes

Abstract

Aim: The aim of this study was to investigate the relationship between body mass index and serum visfatin and metabolic parameters in subjects with different body mass indexes. Methods: Patients enrolled in this study were applied a questionnaire including their personal information, dietary habits and status of physical activities. Their length and body weight were measured, body mass indexes were calculated, and body fat percentage and waist circumference were measured. In addition, routine biochemical parameters (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, fasting blood glucose, fasting insulin) and serum visfatin levels of patients were measured, and they were evaluated according to their body mass indexes. Results: Serum visfatin levels of patients were not found to be correlated with their age, gender and waist circumference, but a moderate negative correlation was determined with body fat percentage. Also there was a negative correlation between body mass indexes and serum visfatin level. While there was no statistically significant relation between serum visfatin level and cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol as well as VLDL-cholesterol, a negative correlation was found between serum visfatin and fasting glucose and fasting insulin levels. Conclusion: Serum visfatin levels resulted lower in patients with high body mass indexes. Negative correlation between serum visfatin levels and fasting blood glucose as well as fasting blood insulin indicates that serum visfatin levels may be associated with the mechanism of insulin resistance in obesity. Keywords: visfatin, body mass index, metabolic profile