Affiliation:
1. Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences
2. Institute of Organic Chemistry with Centre of Phytochemistry
3. The Liver Center, Dalai Tower
Abstract
The phytochemical study of Leptopyrum fumarioides started in 2011 and since then 14 volatile compounds have been identified by GC-MS. 7 flavonoids and 4 alkaloids have been isolated and 2 of them have been recognized as new natural compounds. The structures of the natural products have been determined and ascertained by MS, as well as IR, 1D NMR and 2D NMR spectroscopic methods. The antioxidant, antimutagenic, antiproliferative, hepatoprotective, immunomodulatory, and anticancer activity of Leptopyrum fumarioides extracts and some isolated pure compounds were examined. The new alkaloids leptopyrine (3) and leptofumarine (4) were identified. Leptopyrine (3) is a new type of dimer alkaloid of benzylisoquinoline and simple isoquinoline with imine nitrogen. Leptofumarine (4) is the first example of aporphine and benzylisoquinoline alkaloid with two ether bridges which have head-to-head and tail-to-tail coupling. This review clearly shows that the phytochemical study of plant species is just beginning and requires more detailed and comprehensive study.
Publisher
Irkutsk National Research Technical University
Reference26 articles.
1. Tserenbaljid G. The colored album of flora of Mongolia. Ulaanbaatar; 2002, p. 47-88.
2. Urgamal M., Oyuntsetseg B., Nyambayar D., Dulamsuren Ch. Conspectus of the vascular plants of Mongolia: monograph. Ulaanbaatar: Admon Press; 2014. 282 p.
3. Gubanov I. A. Conspectus of the flora of Outer Mongolia (vascular plants). Moscow: Valang; 1996. 136 p. (In Russian).
4. Hsiao P.-K., Wang W.-T. A new genus of Ranunculaceae-Dichocarpum. Journal of Systematics and Evolution. 1964;9(4):315-334.
5. Moulis C., Gleye J., Stanislas E. Isopyrum thalictroid alkaloids–quaternary leaf bases–isolation and identification of four pseudoprotoberberines. Phytochemistry. 1977;16(8):1283-1287. (In French). https://doi.org/10.1016/S0031-9422(00)94375-9.