Analytical Studies and Biological Activity of New Azo Dye and Its Complexation with Zinc-Reference-Cited by-同舟云学术

Analytical Studies and Biological Activity of New Azo Dye and Its Complexation with Zinc

Published:2023-01-01 Issue:1 Volume:2 Page:31-38
ISSN:2957-5826
Container-title:Biomedicine and Chemical Sciences
language:
Short-container-title:BCS

Author:

Mohsin Ali Kamil,Ali Hanan M.

Abstract

Azo dye (AD), (Z)-5-amino-2-(((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl) phenyl) sulfonyl) diazenyl) phenol) and its complex with zinc were prepared and characterized using FTIR, UV-visible, elemental analysis and mass spectrum. Analytical studies showed that this dye had high solubility in ethanol and gave three isopiestic points when studying the pH effect in a range of buffer solutions. The protonation constants pKb1 and pKb2 of nitrogen atom and the ionization constant pKa of OH-group were equal to 3.4, 7.26 and 10.5 respectively. These results indicated the suggested ionization scheme in acidic and basic media. Further, the synthetic AD was provided non-toxic effects using different concentrations, and did not show any heamolysis effects in the cells in contrast with another chemical compound. The new AD is considered as novel medicine or chemical sanitizer. Further, the biological activity of AD and its complex was tested against four different bacteria, (Staphylococcus Aureus, Escherichia Coli, Bacillus Cereus and Pseudomonas Aeruginosa) and two different fungi (Aspergillus Albicans and Candida Albicans). The results showed that the complexation of AD with zinc was decreased the biological activity of synthetic AD.

Publisher

International Research and Publishing Academy

Reference18 articles.

1. . Kirkan B. and Gup, R. ''Synthesis of New Azo Dyes and Copper (II) Complexes Derived from Barbituric Acid and 4- Aminobenzoylhydrazone'', Turk. J. Chem., 2008, 32, 9-17.

2. . Majeed H., Synthesis, Characterization and study of the spectral and electronic properties of a New Azo Dyes Compounds, J. Thi-Qar Sci, 2013, 4, 91 - 101.

3. . Ali H., Majeed H. and Hussain A., Synthesis, Analytical and Theoretical studies of (Z)-4amino-3-hydroxy-2-((4-(N- (5-methyl isoxazol-3yl) sulfamoyl) phenyl) diazenyl) naphthalene-1-Sulfonic Acid, Journal of Natural Sciences Research, 2017, 7, 81- 88. 16.

4. . Ali H., Majeed H., Al-Asadi I., Abdulredha A. and Hussain A., Structures effect of two azo dyes associated with their antimicrobial activity, Journal of Chemical, Biological and Physical Sciences, 2018, 8, 171-185.

5. . Fayadh R., Ali A. and Al – Jabri F., Synthesis and Identification Symmetrically Azo Dyes Derived from Sulfa Compounds and Spectrophotometric study of Nickel (II) Complexes with Prepared Dyes, International Journal of Engineering and Technical Research (IJETR), 2015, 3, 25-28.