Indicators of Blood Glucose Imbalance in Children with Beta-thalassemia Major

Abstract

Children diagnosed with beta-thalassemia major have a significantly increased likelihood of developing an imbalance in their blood glucose levels. It is essential to do screenings for diabetes and prediabetes in children, and to maintain a high degree of suspicion for abnormalities in blood glucose levels, since this is important for their management. Additionally, it is crucial to acknowledge other markers of blood glucose imbalance, including the glycated hemoglobin level, the fructosamine level, and the occurrence of hypoglycemic crises. Implementing preventive measures and closely monitoring one's health can effectively hinder the path towards diabetes. Thalassemia is a prevalent hereditary blood condition. The need for frequent blood transfusions in thalassemia leads to an excess of iron in the body, which has a role in the development of several disorders, including those affecting insulin production and function. This review examines the several markers of blood glucose dysregulation in children diagnosed with beta-thalassemia major. It also explores the impact of iron overload and other factors, such as the effects of desferioxamine and deferasirox. The review also discusses strategies for preventing diabetes and emphasizes the significance of a multidisciplinary team in caring for these youngsters