Cefpodoxime Concentrations in Human Serum and Oral Tissues Following a Single Oral Administration of Cefpodoxime Proxetil

Author:

Ono Makiko12,Omata Hiroaki1,Nishimura Hitoshi12,Tanaka Shigeo12,Matsumoto Hiroko32,Fujii Akira4,Akimoto Yoshiaki1,Komiya Masamichi12

Affiliation:

1. Departments of Oral Surgery, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, 271-8587, Japan

2. Resarch Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, 271-8587, Japan

3. Departments of Pharmacology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, 271-8587, Japan

4. Professor Emeritus, Nihon University, 4-8-24 Kudan-Minami, Chiyoda, Tokyo 102-8275, Japan

Publisher

Nihon University School of Dentistry at Matsudo Research Institute of Oral Science

Reference20 articles.

1. 1. Jones RN, Barry AL: Antimicrobial activity and disk diffusion susceptibility testing of U-76,253A(R-3746), the active metabolite of the new cephalosporin ester, U-76,252(CS-807). Antimicrob Agents Chemother, 32: 443-449, 1988.

2. 2. Komai T, Kawai K, Tsubake H, Tokui T, Kinoshita T, Tanaka M: Absorption, distribution, metabolism, and excretion of CS-807, a new oral cephem antibiotic, in experimental animals. Chemotherapy(Tokyo), 36(Suppl. 1): 229-240, 1988.

3. 3. Yokota T, Suzuki E, Arai K: Cefpodoxime proxetil, its in vitro antibacterial activity, affinity to bacterial penicillin-binding proteins, and synergy of bactericidal activity with serum complement and mouse-cultured macrophages. Drugs Exp Clin Res, 14: 495-500, 1988.

4. 4. Fass RJ, Helsel VL: In vitro activity of U-76,252(CS-807), a new oral cephalosporin. Antimicrob Agents Chemother, 32: 1082-1085, 1988.

5. 5. Jones RN, Barry AL, Pfaller M, Allen SD, Iyers LW, Fuchs PC: Antimicrobial activity of U-76,252(CS-807), a new orally administered cephalosporin ester, including recommendations for MIC quality control. Diagn Microbiol Infect Dis, 9: 59-63, 1988.

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1. Pharmacokinetics of Antibacterial Agents in the Elderly: The Body of Evidence;Biomedicines;2023-06-04

2. Cefpodoxime proxetil;Profiles of Drug Substances, Excipients and Related Methodology;2019

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