Asymptomatic Cerebral Microbleeds Seen in Healthy Subjects Have a Strong Association With Asymptomatic Lacunar Infarction

Author:

Igase Michiya12,Tabara Yasuharu32,Igase Keiji4,Nagai Tokihisa1,Ochi Namiko12,Kido Tomoko12,Nakura Jun1,Sadamoto Kazuhiko4,Kohara Katsuhiko1,Miki Tetsuro12

Affiliation:

1. Department of Geriatric Medicine, Ehime University Graduate School of Medicine

2. Anti-Aging Center, Ehime University Hospital

3. Department of Fundamental Medical Science, Ehime University Graduate School of Medicine

4. Department of Neurosurgery, Washokai Sadamoto Hospital

Publisher

Japanese Circulation Society

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference21 articles.

1. 1. Roob G, Kleinert R, Seifert T, Lechner A, Kapeller P, Kleinert G, et al. Indications of cerebral micro-hemorrhage in MRI: Comparative histological findings and possible clinical significance. Nervenarzt 1999; 70: 1082-1087.

2. 2. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: Evidence of microangiopathy-related microbleeds. Am J Neuroradiol 1999; 20: 637-642.

3. 3. Wardlaw JM, Lewis SC, Keir SL, Dennis MS, Shenkin S. Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions. Stroke 2006; 37: 2633-2636.

4. 4. Naka H, Nomura E, Wakabayashi S, Kajikawa H, Kohriyama T, Mimori Y, et al. Frequency of asymptomatic microbleeds on T2*-weighted MR images of patients with recurrent stroke: Association with combination of stroke subtypes and leukoaraiosis. Am J Neuroradiol 2004; 25: 714-719.

5. 5. Imaizumi T, Honma T, Horita Y, Chiba M, Kawamura M, Miyata K, et al. Dynamics of dot-like hemosiderin spots on T2*-weighted MRIs associated with stroke recurrence. J Neuroimaging 2007; 17: 204-210.

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