Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of OPC-61815, a Prodrug of Tolvaptan for Intravenous Administration, in Patients With Congestive Heart Failure ― A Phase II, Multicenter, Double-Blind, Randomized, Active-Controlled Trial ―
Author:
Affiliation:
1. Kawaguchi Cardiovascular and Respiratory Hospital
2. Clinical Development Headquarters, Otsuka Pharmaceutical Co., Ltd.
3. Medical Affairs, Otsuka Pharmaceutical Co., Ltd.
Publisher
Japanese Circulation Society
Subject
Cardiology and Cardiovascular Medicine,General Medicine
Link
https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-21-0430/_pdf
Reference21 articles.
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2. 2. O’Connor CM, Stough WG, Gallup DS, Hasselblad V, Gheorghiade M. Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: Observations from the IMPACT-HF registry. J Card Fail 2005; 11: 200–205.
3. 3. Sato N, Kajimto K, Keida T, Mizuno M, Minami Y, Yumino D, et al. Clinical features and outcome in hospitalized heart failure in Japan (from the ATTEND registry). Circ J 2013; 77: 944–951.
4. 4. Boorsma EM, Ter Maaten JM, Damman K, Dinh W, Gustafsson F, Goldsmith S, et al. Congestion in heart failure: A contemporary look at physiology, diagnosis and treatment. Nat Rev Cardiol 2020; 17: 641–655.
5. 5. Goldsmith SR, Bart BA, Burnett J. Decongestive therapy and renal function in acute heart failure: Time for a new approach? Circ Heart Fail 2014; 7: 531–535.
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