Low Heart Rate Variability and Sympathetic Dominance Modifies the Association Between Insulin Resistance and Metabolic Syndrome ― The Toon Health Study ―

Author:

Saito Isao1,Maruyama Koutatsu2,Eguchi Eri3,Kato Tadahiro4,Kawamura Ryoichi5,Takata Yasunori5,Onuma Hiroshi5,Osawa Haruhiko5,Tanigawa Takeshi2

Affiliation:

1. Department of Community Health Systems Nursing, Ehime University Graduate School of Medicine

2. Department of Public Health, Juntendo University Graduate School of Medicine

3. Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

4. Center for Education and Educational Research, Faculty of Education, Ehime University

5. Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine

Publisher

Japanese Circulation Society

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference26 articles.

1. 1. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640–1645.

2. 2. Reaven GM. Banting lecture 1988: Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–1607.

3. 3. DeFronzo RA. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: The missing links [The Claude Bernard Lecture 2009]. Diabetologia 2010; 53: 1270–1287.

4. 4. Saito I. Epidemiological evidence of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease in Japan. Circ J 2012; 76: 1066–1073.

5. 5. Noda H, Iso H, Saito I, Konishi M, Inoue M, Tsugane S. The impact of the metabolic syndrome and its components on the incidence of ischemic heart disease and stroke: The Japan Public Health Center-based study. Hypertens Res 2009; 32: 289–298.

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