Effect of Cumulative Exposure to Low-Density Lipoprotein-Cholesterol on Cardiovascular Events in Patients With Familial Hypercholesterolemia

Author:

Tada Hayato1,Okada Hirofumi1,Nohara Atsushi2,Yamagishi Masakazu3,Takamura Masayuki1,Kawashiri Masa-aki1

Affiliation:

1. Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences

2. Department of Genetics, Ishikawa Prefectural Central Hospital

3. Osaka University of Human Sciences

Publisher

Japanese Circulation Society

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference23 articles.

1. 1. Goldstein JL, Hobbs HH, Brown MS. Familial hypercholesterolemia. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill, 2001; 2863e913.

2. 2. Mabuchi H. Half a century tales of familial hypercholesterolemia (FH) in Japan. J Atheroscler Thromb 2017; 24: 189–207.

3. 3. Beheshti SO, Madsen CM, Varbo A, Nordestgaard BG. Worldwide prevalence of familial hypercholesterolemia: Meta-analyses of 11 million subjects. J Am Coll Cardiol 2020; 75: 2553–2566.

4. 4. Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus statement of the European Atherosclerosis Society. Eur Heart J 2013; 34: 3478–3490a.

5. 5. Ference BA, Majeed F, Penumetcha R, Flack JM, Brook RD. Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: A 2×2 factorial Mendelian randomization study. J Am Coll Cardiol 2015; 65: 1552–1561.

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