Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential
Author:
Affiliation:
1. Department of Pharmacology, Faculty of Medicine, Toho University
2. Department of Aging Pharmacology, Faculty of Medicine, Toho University
Publisher
Japanese Circulation Society
Subject
Marketing,Organizational Behavior and Human Resource Management,Strategy and Management,Drug Discovery,Pharmaceutical Science,Pharmacology
Link
https://www.jstage.jst.go.jp/article/circrep/3/9/3_CR-21-0061/_pdf
Reference14 articles.
1. 1. Suleyman T, Tevfik P, Abdulkadir G, Ozlem S. Complete atrioventricular block and ventricular tachyarrhythmia associated with donepezil. Emerg Med J 2006; 23: 641–642.
2. 2. Leitch A, McGinness P, Wallbridge D. Calculate the QT interval in patients taking drugs for dementia. BMJ 2007; 335: 557.
3. 3. Tanaka A, Koga S, Hiramatsu Y. Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de pointes. Intern Med 2009; 48: 1219–1223.
4. 4. Takaya T, Okamoto M, Yodoi K, Hata K, Kijima Y, Nakajima H, et al. Torsades de pointes with QT prolongation related to donepezil use. J Cardiol 2009; 54: 507–511.
5. 5. Hadano Y, Ogawa H, Wakeyama T, Iwami T, Kimura M, Mochizuki M, et al. Donepezil-induced Torsades de pointes without QT prolongation. J Cardiol Cases 2013; 8: e69–e71.
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