Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential ― Reply ―
Author:
Affiliation:
1. Department of Internal and Cardiovascular Medicine, Tarumizu Chuo Hospital, Tarumizu Municipal Medical Center
2. Pharmaceutical Department, Tarumizu Chuo Hospital, Tarumizu Municipal Medical Center
Publisher
Japanese Circulation Society
Subject
Marketing,Organizational Behavior and Human Resource Management,Strategy and Management,Drug Discovery,Pharmaceutical Science,Pharmacology
Link
https://www.jstage.jst.go.jp/article/circrep/3/9/3_CR-21-0086/_pdf
Reference8 articles.
1. 1. Kuwahata S, Takenaka T, Motoya T, Masuda K, Yonezawa H, Shinchi S, et al. Effect of QT prolongation in patients taking cholinesterase inhibitors (donepezil) for Alzheimer’s disease. Circ Rep 2021; 3: 115–121.
2. 2. Hagiwara-Nagasawa M, Kambayashi R, Goto A, Nunoi Y, Izumi-Nakaseko H, Chiba K, et al. Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones. Naunyn Schmiedebergs Arch Pharmacol 2021; 394: 581–589.
3. 3. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998; 98: 1928–1936.
4. 4. Shimizu M, Ino H, Okeie K, Yamaguchi M, Nagata M, Hayashi K, et al. T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion. Clin Cardiol 2002; 25: 335–339.
5. 5. Riza Demir A, Celik Ö, Sevinç S, Uygur B, Kahraman S, Yilmaz E, et al. The relationship between myocardial fibrosis detected by cardiac magnetic resonance and Tp-e interval, 5-year sudden cardiac death risk score in hypertrophic cardiomyopathy patients. Ann Noninvasive Electrocardiol 2019; 24: e12672.
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1. Action Mechanisms of Donepezil in Cardiac and Vascular Aspects: A Review;2023
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