Podocytes and the actin cytoskeleton as a feasible therapeutic target
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Published:2017-03-17
Issue:4
Volume:118
Page:
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ISSN:1849-0964
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Container-title:Periodicum Biologorum
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language:
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Short-container-title:Period Biol
Author:
Sever Sanja,Gu Changkyo
Abstract
Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as a feasible therapeutics for treating chronic kidney diseases
Publisher
Hrvatski Prirodoslovno Drustvo (Croatian Society for Natural Sciences)
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
1 articles.
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1. The 40th Anniversary of the HDBMB;Periodicum Biologorum;2017-03-17