Author:
MARUYAMA SHOICHI,CANTU EDWARD,DEMARTINO CESARE,VLADUTIU ADRIAN,CALDWELL PETER R. B.,WANG CATHERINE Y.,D'AGATI VIVETTE,GODMAN GABRIEL,STERN DAVID M.,ANDRES GIUSEPPE
Abstract
Abstract. In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.
Publisher
American Society of Nephrology (ASN)
Subject
Nephrology,General Medicine
Cited by
4 articles.
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