ASSOCIATION OF MMP-9 GENETIC POLYMORPHISM AND ММР-9 CONCENTRATION WITH ECHOCARDIOGRAPHIC PARAMETERS IN UKRAINIAN PATIENTS WITH CORONARY ARTERY DISEASE

Abstract

Introduction. Cardiovascular diseases are the main cause of reduced life expectancy, workability, and death among the people of Eastern Europe. Matrix metalloproteinase-9 (MMP-9) is known as one of the leading factors involved in the development and progression of atherosclerosis and heart remodeling. The increasing sizes of the heart’s chambers lead to changes in the electrophysiological properties of the myocardium and to the subsequent occurrence of arrhythmias and conduction disorders. Materials and methods. The study included 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS) and 63 patients with chronic coronary syndrome (CCS) to investigate the effect of MMP-9 polymorphism and its serum concentration on changes in echocardiographic parameters. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus and ELISA study was performed to measure the MMP-9 plasma concentration. Results. Statistically significant differences were found in the thickness of the posterior wall of the heart among carriers of the G-allele and AA-homozygotes for the MMP-9 rs17576-single nucleotide polymorphism but only in patients with ACS. The size of the left ventricle posterior wall can be predicted for carriers of these genotypes. Conclusions. The study revealed no statistically significant relationship between MMP-9 concentration and echocardiographic parameters in patients with ACS and CCS. However, there were statistically significant differences in the left atrium diameter and thickness of the posterior wall of the left ventricle depending on the genotype for MMP-9 rs17576-single nucleotide polymorphism only in patients with ACS. The size of the posterior wall of the left ventricle can be predicted for carriers of AG and GG genotypes.