Severe pneumonia caused by Chlamydia psittaci: report of two cases and literature review
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Published:2022-06-30
Issue:06
Volume:16
Page:1101-1112
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ISSN:1972-2680
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Container-title:The Journal of Infection in Developing Countries
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language:
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Short-container-title:J Infect Dev Ctries
Author:
Dai Nini,Li Qiuyu,Geng Jiayi,Guo Wei,Yan Wei
Abstract
Introduction: Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Its clinical manifestations are nonspecific. Diagnosis of the disease is difficult. In recent years, next-generation sequencing has played an important role in pathogen detection. We report two cases with severe Chlamydia psittaci pneumonia confirmed by next-generation sequencing.
Case Study: The first case is that of a 50-year old man who presented with high fever for four days and cough with sputum for two days. The second case is that of a 57-year-old man who was admitted with high fever for one week, dyspnea and cough with sputum for four days. The second man worked at a chicken farm in the last two months. In both cases, the usual laboratory examination for pathogens detection was negative, and the initial anti-infectious therapy had limited effect. The bronchoalveolar lavage fluid of case 1 and the blood and sputum of case 2 were sent for next-generation sequencing which resulted in sequence reads of Chlamydia psittaci. Antibiotics were adjusted according to the diagnosis.
Results: The diagnosis of the two cases was confirmed by next-generation sequencing detecting Chlamydia psittaci, and the patients had positive results after treatment.
Conclusions: The two cases suggest that next-generation sequencing could be used in early diagnosis of Chlamydia psittaci infection to initiate specific anti-infection therapy in time.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Beijing Municipality
Peking University
Publisher
Journal of Infection in Developing Countries
Subject
Virology,Infectious Diseases,General Medicine,Microbiology,Parasitology
Cited by
5 articles.
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