Author:
Siddiqui Shireen,Malik Abida,Shukla Indu,Rizvi Meher,Haque Shahzad F.
Abstract
Background: This study was conducted to determine the efficacy of four doses of 40 µg vaccine in chronic kidney disease patients as compared to the three-dose 20 µg vaccine schedule given to the normal healthy population. Methodology: This study included 130 chronic kidney disease patients. Of these 84 were given 20 µg vaccine (52 patients were given three doses at 0, one and two months, and 32 patients were given four doses at 0, one, two and six months) and 46 patients were given 40 µg vaccine (30 patients were given three doses at 0, one and two months and 16 patients were given four doses at 0, one, two and six months). Patient response was assessed by measuring antibodies to hepatitis B surface antigen (anti HBs) one month after receiving the third and fourth doses each. Results: Of the patient who received three doses of 20 µg vaccine, 57.7% showed seroprotection while 68.7% of the patients who received four doses of this vaccine showed seroprotection. In contrast, 60% of the patients who received three doses of 40 µg vaccine had seroprotective antibody titers while 87.5% of the patients receiving four doses of 40 µg vaccine showed seroprotection. Conclusions: Seroprotection after four doses of 40 µg vaccine at 0, one, two, and six months was found to be better and cost effective in chronic kidney disease patients compared to three doses of 20 µg vaccine given to normal healthy individuals with adequate renal function.
Publisher
Journal of Infection in Developing Countries
Subject
Virology,Infectious Diseases,General Medicine,Microbiology,Parasitology
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献