Affiliation:
1. Harran Üniversitesi Tıp Fakültesi
2. HARRAN UNIVERSITY
3. HARRAN ÜNİVERSİTESİ
4. HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ
Abstract
Background: To determine plasma free amino acid (FAA) and carnitine levels in pregnant women with hydatidiform mole (HM).
Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatography/tandem mass spectrometry (LC-MS).
Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group (p = 0.019, p = 0.009, and p = 0.03, respec-tively). In addition, several carnitines, C8DC, C16:1, and C18, of the 27 carnitines examined were significantly higher in the HM group than in the control group (p = 0.021, p = 0.03, and p = 0.021, respectively).
Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.
Publisher
Harran Universitesi Tip Fakultesi Dergisi
Reference27 articles.
1. 1. Landolsi H, Missaoui N, Brahem S, Hmissa S, Gribaa M, Yacoubi MT. The usefulness of p57(KIP2) immunohistoc-hemical staining and genotyping test in the diagnosis of the hydatidiform mole. Pathol Res Pract. 2011 Aug 15;207(8):498-504.
2. 2. Shamshiri Milani H, Abdollahi M, Torbati S, Asbaghi T, Azargashb E. Risk Factors for Hydatidiform Mole: Is Hus-band’s Job a Major Risk Factor? Asian Pac J Cancer Prev. 2017 Oct 26;18(10):2657-62.
3. 3. Shih IeM. Gestational trophoblastic neoplasia--pathogenesis and potential therapeutic targets. Lancet Oncol. 2007 Jul;8(7):642-50.
4. 4. Hui P, Buza N, Murphy KM, Ronnett BM. Hydatidiform Moles: Genetic Basis and Precision Diagnosis. Annu Rev Pathol. 2017 Jan 24;12:449-85.
5. 5. Lurain JR. Gestational trophoblastic disease I: epidemio-logy, pathology, clinical presentation and diagnosis of ges-tational trophoblastic disease, and management of hyda-tidiform mole. Am J Obstet Gynecol. 2010;203(6):531-9.