Author:
Anuar Nursyazwani, ,Mohamad Taib Mohamad Nurul Azmi,Mohd Hanafiah Khayriyyah,Al Shammary Aemen Ali Kudayr,Shalan Nur Shazieyatul Nadiah,Che Humaidi Siti Nur Izaty,Awang Khalijah, , , , , ,
Abstract
A series of 1ʹ-acetoxychavicol acetate analogues were synthesised and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) using broth microdilution technique. The minimum inhibitory concentration (MIC) was used to determine whether the compounds had potential as inhibitory agents against the MRSA ATCC 43300, and the compounds with antimicrobial potential (<2000 μg ml–1) were tested for minimum bactericidal concentration (MBC). Based on this assay, compound 1 exhibited potent antimicrobial activity with MIC value of 250 μg ml–1. Meanwhile, compounds 2 and 13 showed the moderate activity with MIC values of 500 μg ml–1, respectively.
Publisher
Penerbit Universiti Sains Malaysia
Subject
General Physics and Astronomy,General Materials Science
Cited by
1 articles.
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