Affiliation:
1. "Bashkir State Medical University" of the Ministry of Health of Russia, Ufa
2. Bashkirian State Medical University
3. Bashkir State Medical Universitey
Abstract
Subject. At the present stage of society development cancer incidence remains among the most pressing medical and social problems. In the structure of oncopathology a special place is occupied by malignant neoplasms of lymphoid and hematopoietic tissues which include chronic myeloid leukemia (CML). In some patients, the disease can appear with dental symptoms associated with a decrease in local immunity of the oral cavity — the appearance of aphthae, plaque on the oral mucosa, angular cheilosis, bleeding gums, dry mouth. It is diagnostically significant that such oral symptoms may precede general clinical symptoms, that is, they can be considered as early symptoms of CML. In addition, their severity often prompts a patient with CML to see a dentist. Thus, the importance of the professional knowledge of the dentist in general clinical and dental symptomatology of CML, the correct routing of the patient for further clinical and laboratory examination, treatment and observation by a hematologist is undeniably high.
The goal is to study and identify the features of the dental status of patients with chronic myeloid leukemia.
Methodology. The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment of patients with chronic myeloid leukemia in which patients with preserved systemic status and patients with chronic myeloid leukemia took part.
Results. According to the results of a complex dental examination and the calculation of the main dental indices, patients with CML were found to have serious disorders in the state of their oral health.
Conclusions. Patients with CML showed a high need for various types of dental care, primarily in conservative oral cavity sanitation, periodontal treatment and rationalization of oral hygiene protocols (professional and individual).
Reference24 articles.
1. Туркина А.Г., Новицкая Н.В., Голенков А.К., Шуваев А.В. и др. Регистр больных хроническим миелолейкозом в Российской Федерации: от наблюдательного исследования к оценке эффективности терапии в клинической практике. Клиническая онкогематология. 2017;10(3):390-401. [A.G. Turkina, N.V. Novitskaya, A.K. Golenkov, A.V. Shuvaev et al. Register of patients with chronic myeloid leukemia in the Russian Federation: from an observational study to evaluating the effectiveness of therapy in clinical practice. Clinical Oncohematology. 2017;10(3):390-401. (In Russ.)]., Turkina A.G., Novickaya N.V., Golenkov A.K., Shuvaev A.V. i dr. Registr bol'nyh hronicheskim mieloleykozom v Rossiyskoy Federacii: ot nablyudatel'nogo issledovaniya k ocenke effektivnosti terapii v klinicheskoy praktike. Klinicheskaya onkogematologiya. 2017;10(3):390-401. [A.G. Turkina, N.V. Novitskaya, A.K. Golenkov, A.V. Shuvaev et al. Register of patients with chronic myeloid leukemia in the Russian Federation: from an observational study to evaluating the effectiveness of therapy in clinical practice. Clinical Oncohematology. 2017;10(3):390-401. (In Russ.)].
2. Туркина А.Г., Зарицкий А.Ю., Шуваев В.А. Клинические рекомендации по диагностике и лечению хронического миелолейкоза. Клиническая онкогематология. 2017:294-316. [A.G. Turkina, A.Yu. Zaritsky, V.A. Shuvaev. Clinical recommendations for the diagnosis and treatment of chronic myeloid leukemia. Clinical Oncohematology. 2017:294-316. (In Russ.)]., Turkina A.G., Zarickiy A.Yu., Shuvaev V.A. Klinicheskie rekomendacii po diagnostike i lecheniyu hronicheskogo mieloleykoza. Klinicheskaya onkogematologiya. 2017:294-316. [A.G. Turkina, A.Yu. Zaritsky, V.A. Shuvaev. Clinical recommendations for the diagnosis and treatment of chronic myeloid leukemia. Clinical Oncohematology. 2017:294-316. (In Russ.)].
3. Сиразетдинова А.Р., Кириллова В.П., Трунин Д.А. и др. Характеристика изменений слизистой оболочки полости рта больных хроническим миелолейкозом на фоне приема иматиниба. Российский стоматологический журнал. 2016;20(1):32-35. [A.R. Sirazetdinova, V.P. Kirillova, D.A. Trunin et al. Characteristics of changes in the oral mucosa of patients with chronic myeloid leukemia while taking imatinib. Russian stomatological journal. 2016;20(1):32-35. (In Russ.)]., Sirazetdinova A.R., Kirillova V.P., Trunin D.A. i dr. Harakteristika izmeneniy slizistoy obolochki polosti rta bol'nyh hronicheskim mieloleykozom na fone priema imatiniba. Rossiyskiy stomatologicheskiy zhurnal. 2016;20(1):32-35. [A.R. Sirazetdinova, V.P. Kirillova, D.A. Trunin et al. Characteristics of changes in the oral mucosa of patients with chronic myeloid leukemia while taking imatinib. Russian stomatological journal. 2016;20(1):32-35. (In Russ.)].
4. Куликов С.В., Виноградова О.Ю., Челышева Е.Ю. и др. Заболеваемость хроническим миелолейкозом в 6 регионах России по данным популяционного исследования 2009-2012 гг. Терапевтический архив. 2014;86(7):24-30. [S.V. Kulikov, O. Yu. Vinogradova, E.Yu. Chelysheva et al. The incidence of chronic myeloid leukemia in 6 regions of Russia according to the population study 2009-2012. Therapeutic archive. 2014;86(7):24-30. (In Russ.)]., Kulikov S.V., Vinogradova O.Yu., Chelysheva E.Yu. i dr. Zabolevaemost' hronicheskim mieloleykozom v 6 regionah Rossii po dannym populyacionnogo issledovaniya 2009-2012 gg. Terapevticheskiy arhiv. 2014;86(7):24-30. [S.V. Kulikov, O. Yu. Vinogradova, E.Yu. Chelysheva et al. The incidence of chronic myeloid leukemia in 6 regions of Russia according to the population study 2009-2012. Therapeutic archive. 2014;86(7):24-30. (In Russ.)].
5. Рябчикова Н.Р., Сафуанова Г.Ш., Никуличева В.И. Эпидемиология хронического миелолейкоза в Республике Башкортостан. Онкогематология. 2018;11(4):349-353. [N.R. Ryabchikova, G. Sh. Safuanova, V.I. Nikulicheva. Epidemiology of chronic myeloid leukemia in the Republic of Bashkortostan. Oncohematology. 2018;11(4):349-353. (In Russ.)]., Ryabchikova N.R., Safuanova G.Sh., Nikulicheva V.I. Epidemiologiya hronicheskogo mieloleykoza v Respublike Bashkortostan. Onkogematologiya. 2018;11(4):349-353. [N.R. Ryabchikova, G. Sh. Safuanova, V.I. Nikulicheva. Epidemiology of chronic myeloid leukemia in the Republic of Bashkortostan. Oncohematology. 2018;11(4):349-353. (In Russ.)].