FEATURES OF THE FUNCTIONAL ACTIVITY OF NEUTROPHILS AND THE LEVEL OF CYTOKINES OF THE LOCAL FOCUS OF INFLAMMATION IN PATIENTS WITH CHRONIC PERIODONTITIS-Reference-Cited by-同舟云学术

FEATURES OF THE FUNCTIONAL ACTIVITY OF NEUTROPHILS AND THE LEVEL OF CYTOKINES OF THE LOCAL FOCUS OF INFLAMMATION IN PATIENTS WITH CHRONIC PERIODONTITIS

Published:2020-08-12 Issue:2 Volume:16 Page:73-78
ISSN:2077-7566
Container-title:Actual problems in dentistry
language:en
Short-container-title:

Author:

Latyushina Larisa¹,Lapteva Anastasiia¹,Plechanova Ekaterina¹,Malysheva Ludmila¹,Shirshova Nataliya¹

Affiliation:

1. South Ural State Medical university

Abstract

Subject. The risks of an unfavorable outcome of simultaneous implantation in most cases are associated with the installation of an implant in the tooth wells with chronic foci of odontogenic infection. The goal is to study the effector indicators of phagocytes and the level of cytokines of the local focus of inflammation in patients with various forms of chronic periodontitis. Methodology. The study involved 65 dental patients with a diagnosis of "K 04.5―K 04.9" (ICD-10, 1997), a comprehensive examination using laboratory immunological methods which included the study of the functional activity of neutrophils (phagocytic activity and intensity on a model of latex particle absorption; lysosomal activity and index of the total luminescence of lysosomes; HCT-reducing activity and intensity according to spontaneous and induced tests) and the concentration of IL-1-RA IL-1β, IL-2, IL-8, IFN–α, IFN-γ (PCG/ml) wound detachable wells of the extracted tooth. Results. A study of the immunological parameters of the local foci of periapical inflammation in patients with various forms of chronic periodontitis revealed some features of the cytokine profile and the functional activity of neutrophils in the wound detachable hole of the extracted tooth. The data obtained in patients with chronic fibrous periodontitis allowed us to determine the signs of activity of chronic inflammation. In subjects who had their teeth removed due to chronic granulating periodontitis, immunological predictors of a prolonged course of inflammatory and reparative processes were revealed. In patients with chronic granulomatous lesions of the periapical zone, evidence of prolonged contamination of the periapical zone was obtained, which may lead to changes in effector parameters against the background of the preserved bactericidal potential of neutrophilic granulocytes. Findings. Immunological predictors of the development of infectious and inflammatory complications were identified in the context of the planned simultaneous dental implantation when implants are inserted into the wells of the teeth with chronic periodontal foci.

Publisher

TIRAZH Publishing House

Reference28 articles.

1. Цитокины в иммунопатогенезе гнойного риносинусита с затяжным и хроническим течением / Л. Ф. Азнабаева, Н. А. Арефьева, П. Н. Машко [и др.] // Российская ринология. – 2004. – № 1. – С. 68–71., Aznabaeva, L. F., Arefieva, N. A., Mashko, P. N. et al. (2004). Tsitokiny v immunopatogeneze gnoynogo rinosinusita s zatyazhnym i khronicheskim techeniyem [Cytokines in the immunopathogenesis of purulent rhinosinusitis with a protracted and chronic course]. Rossiyskaya rinologiya [Russian rhinology], 1, 68–71. (In Russ.)

2. Александрова, Ю. Н. О системе цитокинов / Ю. Н. Александрова // Педиатрия. – 2007. – Т. 86, № 3. – С. 124–128., Alexandrova, Yu. N. (2007). O sisteme tsitokinov [About the system of cytokines]. Pediatriya [Pediatrics], 86, 3, 124–128. (In Russ.)

3. Безрукова, А. П. Пародонтология / А. П. Безрукова. – Москва,1999. – 332 с., Bezrukova, A. P. (1999). Parodontologiya [Periodontology]. Moscow, 332. (In Russ.)

4. Бондаренко, И. В. Современные подходы к иммунопрофилактике и иммунотерапии при операциях на лице и челюстях / И. В. Бондаренко, С. П. Сысолятин, О. В. Бондаренко // Российский стоматологический журнал. – 2006. – № 6. – С. 7–11., Bondarenko, I. V., Sysolyatin, S. P., Bondarenko, O. V. (2006). Sovremennyye podkhody k immunoprofilaktike i immunoterapii pri operatsiyakh na litse i chelyustyakh [Present-day approaches to immunoprophylaxis and immunotherapy in maxillofacial surgery]. Rossiyskiy stomatologicheskiy zhurnal [Russian Dental Journal], 6, 7–11. (In Russ.)

5. Долгушин, И. И. Нейтрофилы и гомеостаз / И. И. Долгушин, О. В. Бухарин. – Екатеринбург, 2001. – 259 с., Dolgushin, I. I., Bukharin, O. V. (2001). Neytrofily i gomeostaz [Neutrophils and homeostasis]. Yekaterinburg, 259. (In Russ.)