CLINICAL EVALUATION OF CHRONIC SIMPLE MARGINAL GINGIVITIS TREATMENT EFFICACY WITH THE USE OF SPRAY AGAINST GUM BLEEDING «DENTABALANCE®» SYNBIOTIC COMPLEX INCLUDING LYSATE FROM STREPTOCOCCUS THERMOPHILUS AND PREBIOTICS (MULTICENTER CLINICAL TRIAL)-Reference-Cited by-同舟云学术

CLINICAL EVALUATION OF CHRONIC SIMPLE MARGINAL GINGIVITIS TREATMENT EFFICACY WITH THE USE OF SPRAY AGAINST GUM BLEEDING «DENTABALANCE®» SYNBIOTIC COMPLEX INCLUDING LYSATE FROM STREPTOCOCCUS THERMOPHILUS AND PREBIOTICS (MULTICENTER CLINICAL TRIAL)

Published:2023-08-21 Issue:2 Volume:19 Page:51-58
ISSN:2077-7566
Container-title:Actual problems in dentistry
language:en
Short-container-title:

Author:

Gileva Ol'ga¹^ORCID,Sadovski Vladimir²^ORCID,Ermolaeva Lyudmila³^ORCID,Libik Tatiana¹^ORCID,Nikolaeva Margarita³^ORCID,Mikhailova Ekaterina³^ORCID,Sycheva Maria⁴^ORCID

Affiliation:

1. Perm State Medical University named after Academician E. A. Vagner

2. JSC "National Institute for Research and Adaptation of Marketing Strategies (NIRAMS)"

3. St. Petersburg State University

4. Academician Ye.A. Vagner Perm State Medical University

Abstract

Subject. The subject of the study is the anti-inflammatory and anti-plaque effect of spray against gum bleeding «DentaBalance®» synbiotic complex in the treatment of chronic simple marginal gingivitis. Objectives. The aim of the study is to conduct a clinical evaluation of spray against gum bleeding «DentaBalance®» synbiotic complex in the complex treatment and hygienic oral care in patients with chronic simple marginal gingivitis (CSMG). Methodology. A pilot open prospective non-randomized multicenter study was conducted to evaluate the anti-inflammatory and anti-plaque effects of spray against gum bleeding «DentaBalance®» synbiotic complex in the treatment of CSMG. The sample consisted of 99 patients aged 20–33 years with CSMG in localized or generalized form, who used spray against gum bleeding «DentaBalance®» synbiotic complex including lysate from Streptococcus Thermophilus and prebiotics 2 times a day for 4 weeks on their own in-home therapy mode. The condition of the gum and oral hygiene was evaluated clinically and objectified indexically (BoP, OHI-S) at 3 observation points: initially, 7 and 28 days after the start of observation. Results. Based on the results of a short-term clinical study, a reliable anti-inflammatory and anti-plaque effect of spray against gum bleeding «DentaBalance®» synbiotic complex was determined. The anti-inflammatory effect was objectified by a significant decrease in the BoP index by 44.7% on the 7th day and by 33.5% additionally on the 28th day of observation. The cleansing effect on the OHI-S index increased from 16.87% on the 7th day of observation to 55.41% at its final stage. The expediency of using spray against gum bleeding «DentaBalance®» synbiotic complex in the complex treatment of CSMG is pathogenetically substantiated, the advantages and prospects of its use in periodontal practice are established. Conclusion. The effectiveness and safety of the spray against gum bleeding «DentaBalance®» synbiotic complex including lysate from Streptococcus Thermophilus and prebiotics for hygienic oral care and effective relief of gum inflammation symptoms in patients with CSMG has been pathogenetically substantiated and clinically proven.

Publisher

TIRAZH Publishing House

Subject

General Medicine

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